Pulmonary cryptococcosis with multiple bone and skin lesions:a case report and literature review
ZHAO Yangyang
LI Ping
YAN Yujie
FENG Youfan
WEI Xiaofang
FU Yuan
HUANG Xiujuan
LI Qingfen
ZHANG Qike
Abstract：Objective A case of pulmonary cryptococcosis with multiple bone destruction and skin damage was reported,and literatures was reviewed.A 36-year-old man was admitted to the hospital with lung mass because of chest tightness,shortness of breath,bone pain and multiple rashes.CT showed suspected lung tumor lesions,multiple ribs and vertebral bone destruction.PET-CT showed multiple bone destruction throughout the body,with multiple fractures of thoracic verte-brae and ribs,and lung lesions were consistent with inflammatory changes.CT-guided percutaneous lung biopsy and bone bi-opsy were confirmed as pulmonary cryptococcosis,while serum protein electrophoresis and serum immunofixation electro-phoresis were weakly positive.Bone marrow biopsy,immunohistochemistry,chromosome analysis and other relevant labo-ratory tests were performed to exclude multiple myeloma.Fluconazole was given and the clinical symptoms improved.Pul-monary cryptococcosis complicated with multiple bone destruction and skin damage was rare and was easy to be confused with tumor disease.The diagnosis method is mainly pathological biopsy.
Keywords：pulmonary cryptococcosislung neoplasmdestruction of bonemultiple myeloma
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 521-524 )