Analysis of infection distribution and drug resistance of invasive yeast in Beij ing Hospital

GAO Zhen-xiang1; TAO Feng-rong2; PIAN Ya-ya1; NIE Jing-jing1; Guo Li-na3; XU Ying-chun3; HU Yun-jian2

doi:10.3969/j.issn.1673-3827.2019.06.005

Abstract：Objective To investigate the infection distribution and to analysis drug sensitivity of invasive yeast in Beijing Hospital from 2012-2013 and 2016-2017. Methods The strains were collected for the clinical detection of invasive yeast. The strain identification and MIC detection were carried out using Komajia chromogenic medium and API20C AUX and VITEK-2 Compact YST card. All strains were also identified by mass spectrometry. Results A total of 62 invasive yeasts were detected in our hospital from 2012-2013，including 36 strains of Candida albicans, accounting for 58.06%;17 strains of Candida glabrata，accounting for 27.41%;5 strains of Candida parapsilosis, accounting for 8.06%;3 strains of Candida tropicalis, accounting for 4.83%;and 1 strain of other Candida，accounting for 1. 60%. In 2016-2017, 43 strains of invasive yeast were detected in our hospital，including 21 strains of Candida albicans, accounting for 48.83%;11 strains of Candida glabrata, accounting for 25.58%;6 strains of Candida parapsilosis，accounting for 13.95%;5strains of Candida tropicalis,accounting for 11.63%. The fungal drug-sensitive results showed that 5-fluorocytosine had different degrees of resistance to Candida albicans, Candida glabrata and Candida tropicalis. Conclusion Candida albicans plays a leading role in invasive yeast infection in our hospital. Although the drug resistance of invasive yeast in our hospital has improved in recent years, further research on fungal drug sensitivity needs to be done.