Echinocandin resistance in Candida
HOU Xin
XU Ying-chun
ZHAO Yu-pei
Abstract：Invasive candidiasis (IC) is an important concern for patients,especially immunocompromised patients.Antifungal therapy is critical for patient,but antifungals are limited.Antifungal resistance,particularly multidrug resistance aggravates this problem.The echinocandins which targeting fungal specific enzyme glucan synthase are the preferred choice to treat IC.The resistance rate of echinocandins has increased recently,and echinocandin resistant isolates are frequently resistant to other antifungals.The mechanism of echinocandin resistance involves amino acid changes of FKS,cellular processes and biofilms.The clinical factors that promote echinocandin resistance include prophylaxis,intra-abdominal candidiasis and host reservoirs.An understanding of the mechanisms and factors that promote echinocandin resistance is critical to develop better diagnostic tools and therapeutic strategies.
Keywords：Echinocandinsinvasive candidiasismechanism of resistanceFKS
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 40-45 )