Molecular regulation on biosynthesis of β-1,3-glucan on cell wall of Aspergillus fumigatus
ZHANG Xi
HAN Li
Abstract：As a major pathogenic fungus,Aspergillus fumigatus is able to cause the invasive pulmonary aspergilosis with high mortality,or chronic infection and allergic disease.β-1,3-glucan is not only the back-bone of cell wall of A.fumigatus,but also an essential immunogenic factor.β-1,3-glucan synthase is composed of a catalytic subunit,Fks and regulatory subunit,Rho1.Rho1 can bind to Fks and regulate the synthesis of β-1,3-glucan through the transformation and modification of its active state.It also may affect cellular translocation and function of Fks by controlling the actin cytoskeleton rearrangement.
Keywords：Aspergillus fumigatusβ-13-glucaninnate immune responseRho-GTPase
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 309-311,317 )