The role of IL-22 in oral candidiasis which caused by Candida albicans
TAN Jing-wen
HE Wen-jing
GAO Zhi-qin
YANG Hong
ZHANG Chu-guang
LIANG Yu-lin
YANG Lian-juan
Abstract：Objective To evaluate the role of IL-22 in oral candidiasis which caused by Candida albicans.Methods We built the models of experimental oral candidiasis in BALB/c mice firstly.Then we used anti-IL-22 antibody to block the immune response.After that we estimate the manifestation of acute oral candidiasis and colonization of C.albicans in the tongue.Histopathological study and the cytokine changes of buccal mucosa were detected either.Results Mice which IL-22 were blocked showed thick pseudomembranous substance on the tongue and the fungal burden reached 1 700 CFU/mL.The normal mice showed thin pseudomembranous substance and the fungal burden was 980 CFU/mL.Histopathological examinations showed hyphae existing on the mucosal surface and invading epithelium accompanied by destruction of epithelium and inflammatory infiltration in the IL-22 blocked mice.Meanwhile,in the normal mice,there were less hyphae existing and rare inflammation.The Real-time PCR showed that compare with wild mice,the fold change of TNF-α,CXCL-9,CXCL-10,CXCL-11 in IL-22 blocked one were 18.1,0.8,1.2 and 0.9 times.Which were 34.5,1.2,6.1and 1.7 times in IL-22 normal mice.Conclusions IL-22 can be protective through enhance the secretion of chemotactic factor in oral candidiasis which caused by C.albicans.
Keywords：Oral candidiasisCandida albicansIL-22
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 207-211 )