Verapamil enhances antifungal activity of itraconazole against Aspergillus fumigatus in vitro
CHEN Pei-ying
ZENG Qiu-qiong
KONG Qing-tao
ZHANG Zheng
ZHANG Ling-li
ZENG Mei-hua
SANG Hong
Abstract：Objective To study the effect of verapamil on antifungal activity of itraconazole against Aspergillus fumigatus in vitro.Methods Colony diameters were measured to compare the drug sensitivity when the strains were inoculated on the media with itraconazole alone and in the combination of verapamil.Spore germination were observated by microscope under itraconazole alone and in the combination of verapamil.Testing for susceptibility to itraconazole was carried out by the brothbased microdilution and E-test methods.Results Colony growth and conidia germination and biofilms were inhibited better under the combination of itraconazole and verapamil than that under itraconazole alone.Conclusions Verapamil enhances antifungal activity of itraconazole against Aspergillus fumigatus in vitro.
Keywords：Aspergillus fumigatusitraconazoleverapamilantifungal activity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 203-206 )