Synergistic effect of mangiferin in combination with fluconazole against fluconazole-resistant Candida albicans
DONG Huai-huai
WANG Yuan-hua
LIAO Ze-bin
JIANG Yuan-ying
CAO Ying-ying
Abstract：Objective To explore the synergistic effect of mangiferin in combination with fluconazole against fluconazole-resistant Candida albicans.Methods The minimal inhibitory concentrations (MIC80) of 22 fluconazole-resistant Candida albicans strains by mangiferin in combination with fluconazole were determined by checkerboard microdilution assay.Time-kill curves and cell growth test were used to investigate the synergistic effect on Candida albcians growth process.The expression of CDR1,CDR2,MDR1 were measured by Real time RT-PCR.Results Mangiferin in combination with fluconazole could inhibit the growth of Candida albicans obviously (FICI＜0.5).Mangiferin and fluconazole-treated cells expressed lower level of CDR1 mRNA than the cells grown in the presence of fluconazole or mangiferin alone.Conclusions Mangiferin possessed a synergistic effect with fluconazole against fluconazole-resistant Candida albcians.
Keywords：fluconazole-resistant Candida albicansmangiferinfluconazole
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 78-82,85 )