Evaluation of clinical efficacy of 1％ luliconazole cream in the treatment of tinea pedis

YANG Jing; DONG Bi-lin; JIANG Ping; YIN Jing; CHEN Zun-yi; ZHANG Wei-ming; XIA Fan; LAI Bin; TONG Zhong-sheng

doi:10.3969/j.issn.1673-3827.2017.01.011

Abstract：Objective To evaluate the efficacy and safety of luliconazole 1％ cream in the treatment of tinea pedis.Methods One hundred and twenty patients positive for fungal elements on direct microscopy were equally and randomly divided into 4 groups:the trial groups applying luliconazole 1％ cream for 2 weeks or 4 weeks and the control groups applying naftifine ketoconazole 2 weeks or 4 weeks.Efficacy was assessed in terms of mycological clearance and clinical response rates on week 2,4 and 6 after initiation of treatment.Results In 2-week regimen,the clinical response rates at weeks 2 were 67.86％ in trial group and 70.37％ in control group (P ＞ 0.05);The mycological clearance rates were 46.43 ％ in trial group and 51.85 ％ in control group (P ＞0.05).They were 85.71％ vs.85.19％ and 82.14％ vs.81.48％ respectively at weeks 4 (2 weeks after the end of treatment)(P＞0.05).In 4-week regimen,the clinical response rates were 88.89％ vs.88.89％ and mycological clearance rates were 85.19％ vs.88.89％ at weeks 4.They were 92.59％ vs.88.89 ％ and 88.89 ％ vs.88.89％ respectively on 2 weeks after the end of treatment (P＞0.05).Treatment-related adverse events consisted of local irritation occurred in 3.33％ of patients both in the trial group and control group.Conclusion The efficacy and safety of 1 ％ luliconazole cream in the treatment of tinea pedis are similar to that of naftifine ketoconazole cream.This study suggests that 1％ luliconazole cream was effective and safe in the treatment of tinea pedis,with the efficacy of 2-week once-daily regimen equivalent to that of 4-week once-daily regimen.