Pattern regcognition receptors and signaling pathways in Cryptococcus neoformans
LI Ying-fang
PAN Wei-hua
Abstract：Pattern recognition receptors (PRRs)presented on the surface of host innate immune cells recognize the patho-gen-associated molecular patterns (PAMPs)of Cryptococcus neoformans after the invasion,which will trigger downstream sinaling pathways and activate nuclear factor-kappa B (NF-κB)in immune cells,ultimately initiating innate and adaptive im-munity,inducing the release of correlative inflammatory factors,activating adaptive immune cells such as Th1,Th2,Th1 7 cells,recruiting macrophage to eliminate Cryptococcus neoformans .Deep insights into PRRs and downstream pathways will contribute to obtain an overall understanding of immune adjustment and provide superior clinical therapys.
Keywords：Cryptococcus neoformanspattern recognition receptors (PRRs)signaling pathwayimmunity
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 58-61 )