Research progress on targeting Hsp90 for antifungal therapy
YANG Su-teng
LIAO Yong
BA Gen
LV Xue-lian
YANG Rong-ya
Abstract：A promising new strategy to enhance the efficacy of antifungal drugs and block the evolution of drug resistance is to target the molecular chaperone Hsp90.For systemic infections,however,effective combination therapy regimens may re-quire Hsp90 inhibitors that can select target Hsp90 in the pathogen.In this review,we summarize studies of the impact of Hsp90 on drug resistance of fungal pathogens and regulation of key fungal virulence traits,regulator of Hsp90 function and the client proteins,and discuss the challenges for development of Hsp90 inhibitors to treat fungal infections.
Keywords：fungusantifungal agentsdrug resistanceheat shock protein 90
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 53-57 )