The sensitivity testing in vitro of major Candida to terconazole
ZHU Junhao
HAN Deming
LI Li
LIU Jianhui
ZHU Xiaochan
ZHANG Qiangqiang
Abstract：Objective To research the sensitivity of major Candida,isolated from severe vulvovaginal candidiasis to terconazole. Methods Isolates were collected from the patients with vulvovaginal candidiasis,who were from the Gynecology clinic of Shanghai Renji Hospital,Shanghai Sixth People's Hospital and Shanghai First Maternity and Infant Hospital.CHROM agar candida medium and API 20C AUX were used to identify Candida species.The sensitivity of 213 Candida isolates to terconazole,clotrimazole and micon?azole were tested by microdilution broth method according to the CLSI M27?A3 microdilution method. Results 192 isolates were i?dentified to C.albicans (90.14%),21 isolates were identified to C.glabrata (9.86%).The sensitivity of C.albicans isolates to tercon?azole were as follows:MIC range:0.024?12.5μg/mL,MIC50:0.39μg/mL,MIC90:1.56μg/mL,GM:0.248μg/mL;The sensitivity of C.glabrata isolates to terconazole were as follows:MIC range:0.024?1.56 μg/mL,MIC50:0.049 μg/mL,MIC90:1.56 μg/mL,GM:0. 107μg/mL.Conclusions Currently vaginal candidiasis infection is still based on C.albicans.The research reprompted terconazole with clotrimazole,miconazole three kinds of antifungal drugs on the 213 Candida have good sensitivity.Terconazole has strong inhibi?tion to C.albicans and C.glabrata and did not find resistance phenomenon.
Keywords：CLSIM27-A3antifungal sensitivityvulvovaginal candidiasisterconazoleclotrimazolemiconazole
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 151-153 )