In vitro susceptibility testing of domestic terbinafine hydrochloride against dermatophytes
TAN Xin
PAN Weihua
DENG Shuwen
GUO Yun
LEI Wenzhi
ZHANG Chao
ZHOU Zhaojing
FANG Wenjie
WEN Yiyang
SHEN Shuaishuai
ZHU Shuang
YAO Zhirong
ZHENG Jie
DENG Danqi
LIAO Wanqing
Abstract：Objectives To investigate the in vitro susceptibility testing of terbinafine against 138 strains of dermatophytes.Meth?ods CLSI M38?A2 guideline was applied.The media containing the fungi in the concentration of(0.4?5)×104 CFU/mL were incuba?ted at 30 for 7 days.The MIC endpoint was determined as the first concentration of antifungal agent that reached 100% inhibition of growth compared with the growth control.The MEC endpoint was determined as the first concentration of antifungal agent that reached 50% inhibition of growth compared with the growth control.Results The tested 138 strains of Dermatophytes were susceptible to ter?binafine,MEC range:0.008?0.125μg/mL,MIC 0.008?0.25μg/mL.There was no statistical differences between Beijia terbinafine and imported terbinafine(P>0.05).Conclusion Beija Terbinafine is active aganist Dermatophytes.It can be an effective choice in super?ficial mycosis treatment.
Keywords：domestic terbinafine hydrochloridedermatophytesin vitroantifungal susceptibility tests
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 22-24,5 )