Detection of helper T cells and regulatory T cells of 21 cases with invasive pulmonary aspergillosis patients
WANG Run-chao
WAN Zhe
LI Ruo-yu
Abstract：Objective To analysis CD4+T cells in peripheral blood mononuclear cell and clinical data of invasive pulmonary as-pergillosis( IPA)patients and explore function of cellular immunity mediated by helper T cells and regulatory T cells in IPA Meth-ods A total of 21 IPA patients were evaluated 19 healthy volunteers as the normal control group We detected Th1,Th2,Th17 and Treg expression in CD4+T cells,related cytokine secretion and key transcription factors of IPA patients and controls Results Pa-tients with IPA exhibited decreased Th1 and Treg expression,related cytokines( IFN-γ,IL-17A,TGF-β)and T-bet,RORγt and Foxp3 mRNA levels when compared with the normal control group while there was no significant difference between patients with IPA and the normal control group about peripheral Th2 frequency,Th2 related cytokines IL-4,and GATA-3 mRNA levels Conclu-sions Th1,Th17and Treg-mediate cellular immunity were inhibited in IPA patients.
Keywords：invasive pulmonary aspergillosishelper T cellsinterleukine-17interferon-γ
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 287-292 )