A case of cutaneous manifestations as an initial presentation of disseminated candidiasis
LIU Fang
ZHANG Min
KONG Qing-tao
YAN Wen-liang
HU Wen-xing
LIU Hai-bo
SANG Hong
Abstract：Objective Disseminated candidiasis is a frequently fatal condition that is rising steadily in immunocompromised pa-tients We reported one case of disseminated candidiasis and reviewed currently available case reports on the cutaneous manifesta-tions of disseminated candidiasis Methods A 37-year-old woman with nodular on lower extremities as the initial presentation,in-volved of the lung and brain She had focal segmental glomerulosclerosis( FSG)undergoing therapy of tacrolimus and prednisone for two years Skin biopsies and culture of skin tissues,stools,urine and sputum were performed Results With microbiological evi-dence of Candida albicans in skin tissue and kinds of excretions except cerebrospinal fluid and blood Chest CT showed bilateral patchy infiltration She was diagnosed as disseminated candidiasis and had anti-fungal therapy A significant improvement of clinical symptoms and resolution of pulmonary were found in following days But she had diffuse brain dissemination after interruption of anti-fungal treatment by herself Conclusions Although widespread organ involvement is characteristic of disseminated candidiasis,re-ports of skin lesions are rare Early cultures and biopsies resulted in early diagnosis,which prompted proper antifungal therapy and a positive outcome.
Keywords：disseminated candidiasisCandida albicanscutanous
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 283-286 )