Comparative diagnostic values of anti-enolase assay and the(1,3)-β-D-glucan assay in early invasive candidiasis
LIAO Hong
LI Fang-qiu
ZHANG Guo-yong
LI Wei
HAN Dan-dan
LIU Qian
Abstract：Objective To compare the anti-enolase(anti-Eno)assay with traditional(1,3)-β-D-glucan(BG)assay for the early diagnosis of invasive candidiasis( IC) Methods Blood samples collected from patients of suspected IC were analyzed with both anti-Eno and BG detection Diagnostic values were compared based upon the results of fungal culture Results A total of 210 patients were enrolled into this study Fifteen patients( 7 1%)were diagnosed as definitive IC by fungal culture Positive results were obtained in 54(25 7%)and 33(15 7%)patients by BG and anti-Eno assay,respectively The sensitivity,specificity,posi-tive predictive value and negative predictive value were 46 7%,86 7%,21 2% and 95 5% in anti-Eno assay while 33 3%,74 9%,9 3% and 93 6% in(1,3)-β-D-glucan assay The sensitivity for IC diagnosis was enhanced to 66 7% upon the combination of anti-Eno and(1,3)-β-D-glucan assay Conclusion Anti-Eno assay is superior to(1,3)-β-D-glucan assay in the diagnosis of early IC Combining these two assays can improve the sensitivity of IC diagnosis.
Keywords：invasive candidiasis(13)-β-D-glucananti-enolase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 272-274,271 )