Antifungal susceptibility testing of clinical isolates of fluconazole-resistant Candida spp. and itraconazole-resistant Aspergillus funmigates to posaconazole
WANG Xue-jie
WAN Zhe
LI Ruo-yu
LIU Wei
Abstract：Objective To determine the in vitro susceptibility of fluconazole( FLU)-resistant Candida spp. and itraconazole (ITC)-resistant Aspergillus spp. to posaconazole(POS). Methods The MICs of FLU,ITC,voriconazole(VRC)and POS were determined according to CLSI M27-A3 and M38-A2 methods in eleven isolates of Candida spp. and three isolates of Aspergillus spp. Results MICs of FLU,ITC,VRC and POS against FLU-resistant Candida spp. were 64 μg/ mL,0. 5 ~ 16 μg/ mL,0. 25 ~ 2 μg/mL and 0. 125 ~ 1 μg/ mL. And MICs of ITC,VRC and POS against ITC-resistant Aspergillus spp. were ﹥ 16 μg/ mL,1 ~ 2 μg/ mL and 0. 25 ~ 0. 5 μg/ mL. Conclusion POS is effective to FLU-resistant Candida spp. and ITC-resistant Aspergillus spp. in vitro .
Keywords：drug resistanceCandidaAspergillus fumigatusposaconazole
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 75-78 )