The application of flupentixol and melitracen in elderly patients with gastrointestinal malignant tumors during the perioperative period

GAO Jin; XU Ning; WANG Huina; Ding Qingzu; YOU Xiaolan

doi:10.3969/j.issn.1674-4136.2026.01.012

Abstract：Objective To comprehensively evaluate the safety,feasibility,and efficacy of flupentixol and melitracen during the perioperative management of elderly patients with gastrointestinal malignancies.Methods In this randomized double-blind study,102 elderly patients with gastrointestinal malignant tumors undergoing surgical treatment were divided into two groups.Fifty-one patients in the study group were given oral or nasogastric feeding flupentixol and melitracen one tablet daily from 3 days before surgery to 1 week after surgery,and 51 patients in the control group were given oral or nasogastric feeding placebo.Hamilton anxiety scale(HAMA)was used to evaluate the anxiety status of patients on the 1st day before operation and 1st,3rd and 5th days after operation.The postoperative recovery was recorded and analyzed.The patients were followed up at 1 week,2 weeks and 1 month after surgery to record the nutritional prognosis index(PNI)and the symptoms related to adverse drug reactions.Results The recovery time of intestinal function and the time of first liquid intake in the study group were earlier than those in the control group(P<0.05).The time of getting out of bed within 5 days after surgery in the study group was significantly longer than that in the control group(P<0.001).The amount of postoperative abdominal drainage fluid in the study group was significantly less than that in the control group(P<0.001).On the 1st,4th,and 7th days after the operation,the C-reactive protein(CRP)in the peripheral blood of the study group was lower than that of the control group,but the difference was not statistically significant(P>0.05).The overall incidence of postoperative complications in the study group was significantly lower than those in the control group(P=0.007).The HAMA scores of the study group were lower than those of the control group on 1st day before surgery and 1st,3rd and 5th days after surgery(P<0.001).The serum prealbumin in the study group was higher than that in the control group on 4th and 7th days after operation(P<0.05).The PNI of the study group was significantly higher than that of the control group at 1 week,2 weeks and 1 month after operation(P<0.05).There was no significant difference in the incidence of adverse reactions of flupentixol and melitracen and placebo between the two groups at 1 week,2 weeks and 1 month after operation(P>0.05).Conclusions Perioperative flupentixol and melitracen is safe and effective in elderly patients with gastrointestinal cancer,which can effectively relieve anxiety/depression and promote postoperative recovery to a certain extent.