Expression and clinical significance of Circ_0084927 and miR-1179 in colorectal cancer patients

CUI Ying; ZHANG Long; LONG Lingyan; HUANG Qinjie

doi:10.3969/j.issn.1674-4136.2026.01.011

Abstract：Objective To investigate the expression and clinical significance of cyclic RNA 0084927(Circ_0084927)and microRNA-1779(miR-1179)in colorectal cancer(CRC)patients.Methods 120 CRC patients admitted to Qidong People's Hospital from January 2019 to May 2021 were selected.Patients were divided into good and poor prognosis groups according to their prognosis;CRC tissues and paracancerous tissues were collected intraoperatively.qRT-PCR was used to detect the expression levels of Circ_0084927 and miR-1179;Pearson correlation analysis was performed to analyze the correlation between Circ_0084927 and miR-1179;χ2 test was used to determine the relationship between Circ_0084927/miR-1179 and clinicopatho-logical charcteristics;Kaplan-Meier survival curves were used to analyze the relationship between Circ_0084927 and miR-1179 with the prognosis of CRC patients;multifactorial COX regression was used to analyze the influencing factors of CRC patients'prognosis;and ROC curves were plotted to analyze the predictive value of Circ_0084927 and miR-1179 on the poor prognosis of CRC.Results The expression level of Circ_0084927 in CRC tissues was significantly higher than that in paracancerous tissues(P<0.05);the expression level of miR-1179 was significantly lower than that in paracancerous tissues(P<0.05).Circ_0084927 and miR-1179 were negatively correlated in CRC tissues(r=-0.783,P<0.05).Circ_0084927 and miR-1179 expression in CRC tissues was associated with clinical characteristics(TNM stage,degree of differentiation and lymph node metastasis)(P<0.05).Circ_0084927 and miR-1179 expression were correlated with clinical characteristics(TNM stage,differentiation degree,lymph node metastasis)(P<0.05).Survival rate of patients with high expression of Circ_0084927 was significantly lower than that of patients with low expression(χ2=12.986,P<0.05);survival rate of patients with high expression of miR-1179 was significantly higher than that of patients with low expression(χ2=11.858,P<0.05).Compared with the good prognosis group,Circ_0084927 expression level was significantly higher(P<0.05)and miR-1179 expression level was significantly lower(P<0.05)in the poor prognosis group.The results of multifactorial COX regression analysis showed that Circ_0084927(HR:3.512,95CI%:1.800-6.852),TNM staging(HR:2.147,95CI%:3.454,95CI%:1.353-8.815)were the risk factors affecting the prognosis of patients with CRC(P<0.05),and the expression level of miR-1179(HR:0.513,95CI%:0.293-0.899)was a protective factor(P<0.05).Circ_008492 and miR-1179 predicted the AUC of poor prognosis of CRC as 0.838 and 0.749,respectively;the combination of the two predicted the AUC of poor prognosis of CRC as 0.856,which was superior to the respective individual prediction(Z=2.635 and Z=2.627,both P<0.05).Conclusions Circ_0084927 expression level was increased and miR-1179 expression level was decreased in CRC tissues.Both were associated with patients'TNM stage,degree of differentiation,lymph node metastasis,and prognosis.In addition,the combined assay of Circ_0084927 and miR-1179 may have a predictive value for poor prognosis of CRC.