The levels and clinical significance of serum GDF-15 and CCL20 in prostate cancer patients
HE Hongyan
AN Ning
CHENG Jiaqi
CHENG Xiaolu
ZHAO Zengxi
ZHANG Rui
MA Lin
Abstract：Objective To clarify the levels and clinical significance of serum growth differentiation factor-15(GDF-15)and chemokine(C—C motif)ligand 20(CCL20)in prostate cancer patients.Methods From January 2022 to September 2024,128 prostate cancer patients accepted by the Second Affiliated Hospital of Heibei North University were included as the research subjects.Complying with the different Gleason scores,scores of 6 or below were considered low-risk,while scores between 7 and 10 were considered high-risk.Therefore,all research subjects were assigned into high-risk group(58 cases)and low-risk group(70 cases).Compare differences in serum GDF-15 and CCL20 levels and the proportion of muscle infiltration between the two groups.Pearson method was used to analyze the correlation between serum GDF-15 and CCL20 in high-risk prostate cancer patients.Logistic method was used to analyze the related factors of high-risk prostate cancer.ROC curve was used to analyze the efficacy of serum GDF-15 and CCL20 in predicting high-risk prostate cancer.Results The proportion of muscle infiltration in the high-risk group was prominently higher than that in the low-risk group(P<0.05).The serum GDF-15 and CCL20 in the high-risk group were prominently higher than those in the low-risk group(all P<0.05).The serum GDF-15 and CCL20 in high-risk prostate cancer patients were positively correlated(r=0.601,P<0.001).Logistic method showed that muscle infiltration,and high serum GDF-15 and CCL20 were independent risk factors for high-risk prostate cancer(all P<0.05).The area under the ROC curve(AUC)of serum GDF-15 and CCL20,and their combination in predicting high-risk prostate cancer was 0.837,0.741,and 0.892,respectively.The combined prediction of the two was superior to the individual diagnoses(all P<0.05).Conclusions Serum GDF-15 and CCL20 are upregulated in high-risk prostate cancer patients,combined detection improves the diagonstic performance for high-risk prostate cancer and has potential clinical value.
Keywords：Prostate cancerGrowth differentiation factor-15Chemokine(C-C motif)ligand 20Clinical significance
Publication Date：2025-08-20
Online Publishing Date：2025-09-15(First online date of this platform, not the publication date of the document)
Pages：5( 350-354 )