The diagnostic value of SWE parameters combined with ultrasound blood flow parameters in benign and malignant thyroid nodules and their association with malignant degree of tumors
DONG Xin
LIU Xuemei
JIANG Yiran
GAO Jingjing
Abstract：Objective To analyze the diagnostic value of shear wave ultrasonic elastography(SWE)combined with ultrasonic blood flow parameters in benign and malignant thyroid nodules and their relationship with the malignant degree of tumors.Methods 100 cases patients with thyroid nodules were selected as the research subjects.All of them treated in Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from January 2022 to December 2024 and underwent SWE and ultrasound blood flow examinations before the operation.Pathological examination of the nodules was conducted after the operation,and the expression of Ki67 and P53 in the nodule tissues was detected by immunohistochemistry.Thyroid nodules were classified into the benign group and the malignant group based on their benign or malignant nature.The levels of SWE parameters,ultrasound blood flow parameters,and the expressions of Ki-67 and P53 were compared between the two groups of patients;To analyze the value of SWE parameters combined with ultrasound blood flow parameters in the diagnosis of benign and malignant thyroid nodules.Spearman correlation analysis was used to analyze the correlations between SWE parameters,ultrasound blood flow parameters and the expressions of Ki-67 and P53.To analyze the value of SWE parameters combined with ultrasound blood flow parameters in the diagnosis of benign and malignant thyroid nodules.Spearman correlation was used to analyze the correlation between SWE parameters,ultrasound blood flow parameters and Ki-67 and P53 expression.Results In 100 cases of thyroid nodules,30 cases were found by pathological examination.Compared with the benign group,the malignant group exhibited significantly higher values in the minimum elastic modulus(Emin),average elastic modulus(Emean),maximum elastic modulus(Emax),peak systolic blood flow velocity(PSV),resistance index(RI),as well as the positive expression levels of Ki-67 and P53(P＜0.05).Conversely,the end-diastolic blood flow velocity(EDV)was significantly lower in the malignant group(P＜0.05).ROC curve results showed that the area under ROC curve(AUC),95%CI and specificity of SWE parameters combined with ultrasonic blood flow parameters in the diagnosis of malignant thyroid nodular tumors were 0.926,0.860-0.991 and 94.30%,respectively,which were higher than the prediction value of the above indexes alone(P＜0.001).Spearman correlation analysis results showed,Emin,Emean,Emax,PSV and RI levels were positively and negatively correlated with Ki-67 score(r=0.649,0.552,0.539,0.415,0.546,P＜0.05),and EDV level was negatively correlated with Ki-67 score(r=-0.401,P＜0.05).Emin,Emean,Emax,PSV and RI levels were positively and negatively correlated with P53 score(r=0.631,0.541,0.524,0.406,0.534,P＜0.05),and EDV level was negatively correlated with P53 score(r=-0.386,P＜0.05).Conclusions The combined examination of SWE parameters and ultrasound blood flow parameters has a high diagnostic value for benign and malignant thyroid nodules,and is closely related to the expressions of Ki-67 and P53,which is helpful for the assessment of the malignancy degree of tumors.
Keywords：Thyroid nodulesBenign and malignantShear wave ultrasonic elastographyUltrasonic blood flow parametersMalignant degree of tumor
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 162-167 )