Evaluation value of preoperative LDH and MBP combined with multi-parameter diffusion magnetic resonance imaging in patients with glioma of different IDH1 genotypes

ZHOU Zhonghui; JIANG Yali; HENG Liang; CHEN Gong; XU Xiao; WANG Sen; WU Yao; ZHANG Yin

doi:10.3969/j.issn.1674-4136.2025.01.011

Abstract：Objective To evaluate the prognostic value of serum lactate dehydrogenase(LDH)and serum myelin basic protein(MBP)combined with multi-parameter diffusion magnetic resonance imaging in patients with different isocitrate dehydrogenase 1(IDH1)genotypes.Methods A total of 100 glioma patients admitted to Friendship Hospital of Yili Kazak Autonomous Prefecture from March 2020 to March 2022 were included,they were divided into two groups according to different IDH1 genotypes:IDH1 mutant group(n=68)and IDH1 wild type group(n=32).LDH and MBP were detected before surgery for all patients,and multi-parameter diffusion magnetic resonance imaging was performed to construct a reconstructed model,multiple parameters,including surface dispersion coefficient(ADC),axial dispersion coefficient(AD),mean dispersion parameter(MD),radial dispersion coefficient(RD)and fractional anisotropy(FA),preoperative LDH,MBP levels and multiple parameters(ADC,AD,MD,RD,FA)were compared between different groups,Multivariate Logistic regression analysis and receiver operating characteristic curve(ROC)were used to evaluate the prognostic value of the above indicators in glioma patients.Results LDH,MBP,AD,MD,RD and FA in the good prognosis group were lower than those in the poor prognosis group,and ADC was higher than those in the poor prognosis group.Compared with the death group and the survival group,LDH,MBP,AD,MD,RD and FA in the death group were higher than those in the survival group,and ADC was lower than those in the survival group(P＜0.05).Logistic multivariate regression analysis showed that LDH≥190 U/L,MBP≥8.5 μg/L,ADC＜0.85,AD≥1.38,MD≥1.12,RD≥1.2,FA≥0.16 were independent risk factors for poor prognosis in patients with glioma(P＜0.05).Conclusions With LDH,MBP,ADC,AD,MD,RD and FA,the AUC for predicting poor prognosis of glioma patients was 0.865,and the sensitivity and specificity were 90.74％and 88.78％.Conclusion Preoperative LDH and MBP combined with multi-parameter diffusion magnetic resonance imaging play an important role in the evaluation of different IDH1 genotypes in glioma patients,and can provide a reliable reference for predicting the prognosis of patients.