Comparison of the clinical efficacy of endoscopic submucosal dissection and laparoscopic radical resection in patients with early-stage colorectal cancer

ZHENG Shudan; YANG Liu

doi:10.3969/j.issn.1674-4136.2025.01.005

Abstract：Objective To explore the comparison of the clinical efficacy of endoscopic submucosal dissection and laparoscopic radical resection for early colorectal cancer patients with early-stage colorectal cancer.Methods A total of 115 patients with colorectal cancer who underwent surgical treatment in Suzhou Municipal Hospital from March 2017 to March 2022 were retrospectively selected.Divided into observation group(57 cases)and control group(58 cases)according to the surgical method,ESD and laparoscopic radical resection were performed,respectively.The surgical indicators,tumor markers,stress level,pain degree,complications and prognosis were compared between the two groups.Results The operation time,bed rest time,first defecation and hospital stay,blood loss and complications in the observation group were less than those in the control group(P＜0.05).After operation,the levels of cytokeratin 19 fragment(CYFRA21-1),carbohydrate antigen 72-4(CA72-4)and Carcinoembryonic Antigen(CEA)in the two groups were lower than those before operation(P＜0.05),but there was no stastistical differences between the two groups after operation(P＞0.05).After operation,the levels of superoxide dismutase(SOD),neuropeptide Y and cortisol in the two groups were higher than those before operation,but those in the observation group were lower than those in the control group(P＜0.05).At 24 and 48 hours after operation,the visual analogue scale(VAS)scores of the two groups gradually increased compared with those before operation,but the VAS scores of the observation group were lower than those of the control group(P＜0.05).Conclusions ESD and laparoscopic radical resection for early colorectal cancer have good clinical efficacy in the clinical treatment of early colorectal cancer,and can effectively reduce the tumor markers,and have a better prognosis,but ESD has less operation time,less blood loss,less postoperative pain,less complications,less clinical surgical trauma than laparoscopic radical resection,which can promote rapid postoperative recovery.