High expression of SRPX2 in gastric cancer tissues is associated with immune infiltration and poor prognosis

SONG Xudong; SHI Jin; DAI Dezhu; DING Fan; GAO Zihao; TAO Guoquan

doi:10.3969/j.issn.1674-4136.2025.01.003

Abstract：Objective To investigate the relationship among the expression of SRPX2(including sushi repeat protein X-linked 2)in gastric cancer tissues,immune cell infiltration and prognosis,in order to further clarify the biological function and prognostic value of SRPX2 in gastric cancer,and provide clues and references for future individualized prevention,diagnosis and treatment.Methods Expression of the SRPX2 gene in pan-and gastric cancers was analyzed using multiple databases,validated using clinical tissue samples and correlated with clinical features.Relationships between SRPX2 and patient overall survival(OS),disease-specific survival(DSS),and progression-free interval(PFI)were analyzed by the Kaplan Meier-Plotter database and R language.PPI analysis and GO/KEGG functional enrichment of SRPX2 co-expressed genes were performed using the STRING database and the GEPIA2 database.The TIMER database was used to analyze the association between SRPX2 expression and immune cell infiltration in gastric cancer tissues.Results Analysis based on TCGA and GEPIA databases suggested that SRPX2 was relatively highly expressed in gastric cancer tissues,which is closely associated with clinicopathologic features.SRPX2 may be an independent prognostic factor for gastric cancer,and high expression of this gene is associated with poor prognosis in gastric cancer.GO/KEGG functional enrichment analysis suggested that SRPX2 was closely related to the"focal adhesion","proteoglycans in cancer"and"protein digestion and absorption"pathways.TIMER database analysis showed that SRPX2 expression was correlated with the infiltration of various immune cells.Conclusions SRPX2 expression is up-regulated in gastric cancer tissues and correlates with immune infiltration of tumor cells and poor prognosis in gastric cancer patients,which could potentially be a molecular target for the treatment of gastric cancer patients as well as for determining their prognosis.