Advances of HER2-targeted therapy for bladder cancer
MA Xiaoyu
CAI Hongzhou
XU Weizhang
XU Zicheng
YU Bin
Abstract：Bladder cancer is the most common urinary system tumor,with a high incidence rate.There are limited treatment strategies for advanced or metastatic bladder cancer,leading to high mortality and poor prognosis.Therefore,finding effective treatment options is crucial for improving prognosis.Based on the significant efficacy of HER2-targeted therapy in other tumor types,such as breast cancer,advanced gastric adenocarcinoma,and gastroesophageal junction adenocarcinoma,and evidence suggesting that HER2 overexpression is present in bladder cancer and is associated with prognosis,HER2-targeted therapy may play an important role in the treatment of advanced or metastatic bladder cancer.This article will provide a review focusing on four aspects:the current treatment landscape of bladder cancer,HER2 and its signaling pathways,HER2 and bladder cancer,and clinical reports on HER2-targeted therapy for bladder cancer.
Keywords：Bladder cancerHER2Targeted therapyClinical reportAdverse reactions
Publication Date：2024-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 614-619 )