Prognostic value of preoperative serum NF-κB and NLRP3 levels in patients undergoing glioma resection
WU Tongshuai
LIU Zhenyang
Abstract：Objective To investigate the prognostic value of preoperative serum levels of nuclear factor kappa-B(NF-κB)and Nod-like receptor pyrin domain 3(NLRP3)in patients undergoing glioma resection.Methods 80 patients undergoing glioma resection in Shanxi Bethune Hospital from January 2020 to January 2023 were selected as the study objects.The patients were followed up for 1 year and divided into a good prognosis group(63 cases)and a poor prognosis group(17 cases)according to the prognosis.The levels of NF-κB and NLRP3 in serum before operation were compared between the two groups.A multi-factorial Logistic regression was conducted to identify factors influencing the prognosis of patients undergoing glioma resection.Receiver operating characteristic curve(ROC)was drawn to evaluate the predicative value of serum NF-κB and NLRP3 levels in patients with glioma resection.Results There In the poor prognosis group,patient's age,maximum tumor diameter,tumor grading,serum levels of NF-κB and NLRP3 was significantly different compared to the good prognosis group(P＜0.05).Multivariate Logistic regression analysis revealed that age,maximum tumor diameter,tumor grading,serum levels of NF-κB and NLRP3 were risk factors for poor prognosis in patients undergoing glioma resection(P＜0.05).ROC curve analysis indicated that the area under the curve for predicting poor prognosis in glioma resection patients using preoperative single serum NF-κB,NLRP3 levels,and their combination were 0.734,0.746 and 0.812,respectively.The specificity was 68.91%,72.21%and 78.63%,respectively.The sensitivity was 75.62%,73.05%and 80.68%,respectively.Conclusions Preoperative serum NF-κB and NLRP3 levels are associated with poor prognosis in patients undergoing glioma resection.They can be used to predict the prognosis of patients undergoing glioma resection,and the combination of the two indexes has a good predictive effect.
Keywords：Nuclear factor kappa-BNod-like receptor pyrin domain 3Glioma resectionPrognosis
Publication Date：2024-08-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 344-348 )