Clinical efficacy evaluation of percutaneous microwave ablation for papillary thyroid microcarcinoma

SU Haobo; HUANG Qian; ZHANG Tao; WANG Wenping

doi:10.3969/j.issn.1674-4136.2024.04.004

Abstract：Objective To investigate and evaluate the clinical efficacy of percutaneous microwave ablation in the treatment of papillary thyroid microcarcinoma(PTMC).Methods One hundred and eight patients with PTMC in the thyroid treatment centers of Jiangsu Cancer Hospital,Nanjing Jiangning Hospital and Nanjing Jiangning Hospital of Traditional Chinese Medicine from April 2016 to May 2018 were selected,with a total of 118 lesions.Real-time ultrasound monitoring and guided microwave complete ablation of local areas were performed;Clinical observation indexes included clinical symptoms and signs,ultrasound imaging,laboratory tests:Thyroid function and peripheral blood immunological indexes(CD4,CD8,CD4/CD8),and the above indexes were followed up and evaluated.Results In all cases of PTMC microwave ablation,thyroid function was normal and no complications occurred after multiple regular follow-up after PTMC microwave ablation(This result belongs to the safety evaluation of the intervention);CD4 and CD4/CD8 levels in peripheral blood before and after the ablation showed an increasing trend;CD8 levels showed a decreasing trend,and the difference in immunological results between time points was statistically significant(P＜0.05);The volume of ablated nodules showed a continuous reduction after the operation and the difference in volume reduction at the 6th,12th and 18th months was statistically significant(P＜0.05);And 44 nodules had completely disappeared at the 18th months(44/118,37.29%).Conclusions The clinical efficacy evaluation shows that percutaneous microwave ablation in the treatment of papillary thyroid microcarcinoma is a new technology that is worthy of clinical application.