Application prospect of cancer fibroblasts as targets in triple negative breast cancer immunotherapy
ZHU Yu
ZHANG Jian
HOU Junchen
XU Di
WANG Dandan
Abstract：It is believed that tumor microenvironment contribute greatly to the progression of a series of cancers,including breast cancer.Cancer associated fibroblasts(CAFs)are the most abundant components of tumor microenvironment.Research has shown that CAFs in cancer originate from various types of cells,promoting the production and progression of malignant tumors by secreting factors,producing exosomes,releasing nutrients,reshaping the extracellular matrix,and inhibiting immune cell function.Due to their specific distribution in tumors and unique biomarkers,CAFs have the potential to become therapeutic targets for cancer.Currently,drugs that block the action of CAFs on surrounding cells have been developed and applied in clinical trials.Further understanding of the mechanisms involved in the tumor promoting and anti-tumor effects of CAFs can provide the possibility of unmapped therapeutic interventions aimed at controlling some matrix properties,further manipulate CAFs and use their biological characteristics to restore the dysfunctional microenvironment and prevent the progress of breast cancer.
Keywords：Breast cancerImmunotherapyTumor MicroenvironmentTumor FibroblastsReview
Publication Date：2024-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 302-307 )