Meta analysis of the relationship between iodine intake and papillary thyroid carcinoma
YU Zhiwei
XU Fei
WANG Ting
Abstract：Objective This study aimed to explore the correlation between iodine intake and papillary thyroid carcinoma(PTC).Methods After formulating a search strategy based on PICOS,12 case-control studies on iodine intake and PTC were collected from PubMed,Cochrane Library,Web of Science,CNKI,and Wanfang databases,including a total of 6 214 research subjects,and Meta-analysis was performed.Results The Meta-analysis indicated that there was a positive correlation between excessive iodine intake and the incidence of PTC(OR=5.66,95％CI:2.25～12.68,P＜0.05),while moderate iodine intake could reduce the risk of PTC(OR=0.26,95％CI:0.13～0.52,P＜0.01).Excessive iodine intake may not be related to such factors as extrathyroidal extension(ENE),the central lymph node metastasis(CLNM),and BRAF gene mutations.Conclusions Excessive iodine intake increases the risk of PTC,and moderate iodine intake may be a protective factor for PTC.
Keywords：Papillary thyroid carcinomaIodineIodine intakeIodine nutritionUrinary iodineMeta-analysis
Publication Date：2024-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 253-260 )