Effect of presence of intraductal carcinoma of prostate in men with high-risk prostate cancer receiving neoadjuvant therapy
WANG Binyu
PENG Shan
FU Yao
CHEN Mengxia
ZHUANG Junlong
GUO Hongqian
QIU Xuefeng
Abstract：Objective To study the effect of presence of intraductal prostate cancer(IDC-P)to locally high-risk prostate cancer patients receiving neoadjuvant therapy.Methods A retrospective study of 80 patients diagnosed as prostate cancer from Nanjing Drum Tower Hospital was conducted to evaluate the association of the presence of IDC-P on biopsy pathology with favorable pathologic objective response after receiving six-month neoadjuvant therapy.Results Patients with IDC-P were associated with higher ISUP(P=0.037),clinical T stage(P=0.036),and nerve invasion(P=0.041).Univariate analysis showed that patients with IDC-P were less likely to appear favorable pathologic response(OR=8.022,95％CI:1.550-41.515,P=0.013).Conclusions Patients with IDC-P were less sensitive to neoadjuvant therapy.
Keywords：Prostate cancerIntraductal carcinoma of prostateNeoadjuvant therapyPathologic objective responseRisk factor
Publication Date：2024-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 242-245 )