Advances in the Molecular Research on the Dedefferentiation Process of Anaplastic Thyroid Cancer
WANG Shuai
WANG Kuanyu
KONG Xiangding
LI Cheng
Abstract：Anaplastic thyroid cancer(ATC)is a rare but extremely aggressive form of thyroid cancer that is fatal to most patients.With the regularization of molecular testing and the continuous development of molecular targeted drugs,molecular targeted therapy has become an important treatment method for anaplastic thyroid cancer.However,there is extensive heterogeneity in the molecular and genetic characteristics of ATC,which makes targeted therapy of ATC more difficult.Many studies have proven that ATC originates from differentiated thyroid carcinoma(DTC)and triggers the dedifferentiation process through specific molecular events.However,the molecular mechanism that triggers this process and maintains the invasiveness of ATC is not fully understood.This article discusses the molecular evolutionary trajectory from DTC to ATC and reviews the relevant molecular mechanisms,which has guiding significance for the diagnosis and treatment of anaplastic thyroid cancer.
Keywords：Thyroid cancerAnaplastic thyroid cancerDifferentiated thyroid cancerMolecular mechanismTargeted therapy
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 196-200 )