Microsurgical treatment and analysis of therapeutic efficacy factors for cerebellopontine angle meningiomas
XU Xiupeng
LIU Ning
Abstract：Objective To explore the strategy of microsurgical treatment for cerebellopontine angle(CPA)meningiomas and to analyze the influencing factors of efficacy.Methods A retrospective review was performed on 137 patients with CPA meningiomas who were consecutively admitted to the Department of Neurosurgery,The First Affiliated Hospital of Nanjing Medical University,from April 2009 to May 2019. The extent of tumor resection was assessed using the Simpson classification.Karnofsky performance status(KPS)scale was used to evaluate the patients. outcomes.Results Among the 137 patients,132 patients underwent tumor resection through suboccipital retrosigmoid approach,and 5 patients underwent tumor resection through subtemporal combined with suboccipital retrosigmoid approach.Simpson Ⅰ-Ⅱ resection was achieved in 122(89.1%)cases,Ⅲ in 11(8%)cases,and Ⅳ in 4(2.9%)cases.All patients were followed up and postoperative follow-up duration was 72.4±20.8 months.Tumor recurrence and progression were identified in 2 cases and 1 case respectively.The KPS at the last visit was 92.3±13.1,which is higher than that at discharge(86.9±9.4)and before operation(75.8±10.3)(both P＜0.001).Univariate analysis indicated that the tumor types(P=0.013),the maximum diameter of the tumor(P=0.023),the peritumoral edema(P=0.005),and the incomplete arachnoid interface(P=0.030)are the risk factors influencing total resection.Conclusions Most CPA meningiomas can be removed through suboccipital retrosigmoid approach.Total resection seems to be easier to be achieved when the tumor is non-convexity type,with a small size,intact arachnoid interface,and without peritumoral edema.
Keywords：Cerebellopontine angleMeningiomasSuboccipital retrosigmoid approachRisk factors
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 122-125 )