Research progress in Superficial CD34-positive Fibroblastic Tumor
LIU Xu
LIU Jiao
CHEN Lu
HU Yuchang
Liu Yufei
Abstract：Superficial CD34-positive fibroblastic tumor(SCPFT/SCD34FT)is a rare mesenchymal tumor newly recognized in recent years,which mainly occurs in the subcutaneous superficial soft tissue of the lower extremities.Patients often see a doctor because of the gradual enlargement of the mass with pain several years later,and there are no special clinical manifestations and laboratory indicators,so the diagnosis depends on pathology.Under the microscope,it can be seen that the relatively mild spindle cells are mixed with strange cells,which are polymorphic,with nucleolus visible but rare mitotic image(≤1/50HPF).Intranuclear pseudoinclusion bodies and eosinophilic granular cytoplasm may appear.There's no tumor necrosis.Immunohistochemical diffuse expression of CD34,Vimentin,WT1,and CADM3/SynCAM3,Ki-67 index is＜1%.PRDM10 gene rearrangement is present in about 42%of cases.The overall prognosis of this tumor is good,recurrence or lymph node metastasis occurred in a few cases,and no deaths have been reported.This article comprehensively reviews all SCPFT reports in domestic and foreign literature,and summarizes them,hoping to provide new understanding and reference for clinicians.
Keywords：Superficial CD34-positive fibroblastic tumorMesenchymal tumorClinical and pathologicalImmunohistochemistryPRDM10
Publication Date：2023-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 621-624 )