Analysis of the effect of tumor resection under a fluorescent microscope guided by yellow fluorescence staining in the treatment of supratentorial glioma

LEI Zhongqi; LIU Jiachuan; WANG Jinbiao; WEN Yudong; YAO Yinsheng; WU Xiaogang; WANG Chunlin

doi:10.3969/j.issn.1674-4136.2023.06.004

Abstract：Objective To analyze the clinical effect of tumor resection under a fluorescent microscope guided by yellow fluorescence staining in the treatment of patients with supratentorial glioma.Methods A total of 98 patients with supratentorial glioma admitted to The No.901 Hospital of the Joint Logistic Support Force of People's Liberation Army from January 2016 to March 2019 were selected and divided into a traditional surgery group(48 cases)and a yellow fluorescence technique group(50 cases)according to different treatment methods.The traditional surgery group was treated with traditional microsurgical tumor resection,while the yellow fluorescence technique group was treated with yellow fluorescence staining technology to guide tumor resection under the microscope.The surgical conditions(operation time,complete tumor resection rate,and postoperative hospital stay),postoperative complications(limb movement disorder,brain edema,and pulmonary infection),as well as preoperative and postoperative Karnofsky Performance Score(KPS)between the two groups were compared.After 2 years of follow-up,progression-free survival(PFS)and overall survival(OS)were compared between the two groups.Results There was no significant difference in the operation time between the two groups(P＞0.05).The tumor complete resection rate in the yellow fluorescence technique group was higher than that in the traditional surgery group(84.00%vs.58.33%),and the hospital stay was shorter than that in the traditional surgery group[(12.86±2.68)%)d vs.(18.41±3.24)d],the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of postoperative complications such as limb movement disorder,brain edema,and pulmonary infection between the two groups(P＞0.05).One month after the operation,the KPS score of the yellow fluorescence technique group was higher than that of the control group[(80.24±13.35)points vs.(74.37±12.33)points],and the difference was statistically significant(P＜0.05).Follow-up showed that there were statistically significant differences in PFS and OS survival curves between the two groups(P＜0.05).Conclusions Yellow fluorescence staining technique guided fluorescence microscope tumor resection in the treatment of supratentorial glioma can increase the complete resection rate of the tumor,shorten the hospital stay of patients,and promote the improvement of postoperative life quality of patients,which has certain clinical significance for improving the prognosis and survival of patients.