The clinical efficacy of neoadjuvant chemotherapy using oxaliplatin and capecitabine in the treatment of advanced colon cancer
SUN Chunhua
XU Xiaojun
GUO Xuedan
ZHAO Fan
Abstract：Objective To investigate the clinical efficacy and adverse reactions during neoadjuvant chemo-therapy using oxaliplatin and capecitabine in the treatment of advanced colon cancer patients. Methods From January 2010 to December 2012, 52 advanced colon cancer patients in WUxi No. 2 hospital were selected and di-vided into 2 group at random. The experimental group was given the combination therapy of oxaliplatin and capecitabine, while the control group was treated with oxaliplatin and 5-FU. Results The objective response rate after 3 course of treatment in the experimental group was 57. 69% , which was better than 23. 07% in the control group, and the difference was statistically significant(P < 0. 05);the occurrence of leucopenia and liver function abnormality in the experimental group was statistically decreased compared with that of the control group, and the difference was statistically significant(P < 0. 05). Conclusions The combination application of oxaliplatin and capecitabine has better therapeutic effect and fewer adverse reactions for treating advanced colon cancer.
Keywords：Colon cancerNeoadjuvant chemotherapyOxaliplatinCapecitabine5-FU
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 387-389,393 )