Effect of different alimentary reconstruction after radical surgery for gastric cancer on blood glucose and gastrointestinal hormones in patients with type 2 diabetes
HE Xiangkun
LU Chunlei
XU Jian
YAO Haojie
GE Chen
WU Guozhong
Abstract：Objective To assess the effect of different alimentary reconstruction on blood glucose and gas-trointestina hormones in gastric cancer patients who suffered type 2 diabetes as well. Methods The retrospec-tive analysis was made in 69 cases of gastric cancer with type 2 diabetes from 2010 to 2015 in the department of general surgery of the 101th Hosptial of PLA. These patients were divided into three groups ,Group A(D2 dis-section with Billroth Ⅱ)has 23 cases, Group B(D2 dissection with Billroth Ⅱ)has 20 cases,Groups C(D2 dis-section with esophago- jejunum or gastro- jejunum Roux-en-Y anastomosis)has 26 cases. The levels of fast blood glucose and 2h postprandial blood glucose ,fast glucagon-like peptide-1(FGLP-1) and 2h postprandial gluca-gon-like peptide-1(2hGLP-1),fast glucose-dependent insulinotropic peptide(FGIP) and 2h postprandial glu-cose-dependent insulinotropic peptide(2hGIP) were detected in patients before enrolled by the hospital,1 week, 1 month,3 months and 6 months after operation in three groups. Results Comparing to the Group C, the level of blood glucose and glucose-dependent insulinotropic peptide showed a steady and sustained descent in patient 1 month and 6 months after surgery in the Group A and Group B(P < 0. 05),and the level of glucagon-like pep-tide-1 appeared a a steady and sustained increase in patients 1 month and 6 months after surgery in the Group A and Group B. But,these changes were not appeared in the Group A. However,there were no differemes between the effective rates for the Billroth Ⅱ and Roux-en-Y groups respectively(P > 0. 05). Conclusion It is an ef-fective method for blood glucose control using surgery of Billroth Ⅱ and Roux- en-Y anastomosis in gastric canc-er patients with type 2 diabetes.
Keywords：Gastric cancerType 2 DiabetesOperationGastrointestinal hormonesAlimentary reconstruction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 360-363 )