Research on the content changes of the STC-1 and its role in the diagnosis of breast cancer
YANG Chuansheng
HUANG Zhan
LUO Zhihui
LEI Ruiwen
CHEN Zhuorong
WU Jiahao
OU Linyang
LI min
Abstract：Objective To investigate the expression level of stanniocalcin-1(STC-1) in peripheral blood of patients with breast cancer and discuss its clinical value as circulating tumor marker. Methods The fluorescent quantitation reverse transcription polymerase chain reaction ( RT-PCR) was used to detect STC-1 in the periph-eral blood of 80 patients with breast cancer,40 patients with breast benign tumors and 30 healthy subjects,and serum carcino-embryonic carbohydrate antigen 125 (CA-125) were detected among 60 patients with breast canc-er and analyzed comparatively. Results The positive rate of STC-1 in 80 patients with breast carcinoma was 43. 8%(35/80),the positive rate of STC-1 in 40 patients with benign tumors was 5. 0%(2/40),but there was no expression of STC-1 in 30 healthy patients. The expression level of STC-1 in peripheral blood of patients with breast cancer was higher than that of breast benign tumors and that of the healthy subjects with statistical signifi-cance. In the detecting process of the breast cancer, the STC-1 was of lower specificity than CA-125;while its sensitivity is higher than that of the CA-125. However,both the specificity and sensitivity were remarkably in-creased when the STC-1 and CA-125 were detected in combination(P<0. 05). Conclusions STC-1 protein expression played an important role in breast cancer initiation and progression,and may be a potential biomarker for prognosis assessment of breast cancer.
Keywords：stanniocalcin-1breast cancertumor markerreverse transcription polymerase chain reactiongene detection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 209-211,212 )