Effects of zhuanggu zhentong capsule on the role of phosphatidyl inositol 3-kinase(PI3K) of nude mouse breast cancer metastatic tumor cells
CAO Jianxiong
YAO Fei
HE Yingchun
BI Sili
WANG Wen-mei
HE dan
LIU Jinghong
Abstract：Objective To discuss zhuanggu zhentong capsule on the role of phosphatidyl inositol 3-kinase of nude mouse breast cancer metastatic tumor cells. Methods 32 nude mice were randomly divided into four groups, named as the prevention group of zhuanggu zhentong capsule;the treatment group of zhuanggu zhentong capsule;the positive drug control group of shenyi capsule and the blank model group. Each group was consisted of eight nude mice. After the nude mice implanted breast cancer cells and drug intervention, we would calculate and contrast the inhibition rate of tumor and phosphatidyl inositol 3-kinase of tumor cells for each group of nude mice. Results Among the positive drug control group, the prevention group and the treatment,it was found that the inhibition to the growth and the expression of PI3-K in human breast cancer cells in nude mice transplanted tumor. But the effect of the prevention group of zhuanggu zhentong capsule was more apparent. Conclusions Zhuanggu zhentong capsule can restrain the activity of phosphatidyl inositol 3-kinase expressed in nude mouse. The effect of the prevention group is better than that of the treatment group.
Keywords：zhuanggu zhentong capsulebreast cancerphosphatidyl inositol 3-kinasePI3-K
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 167-170 )