Correlation analysis between p53 and EGFR expression in distinct molecular subtypes of invasive breast ;cancer
WANG Xinzhao
SUN Jujie
LIU Qi
ZUO Wenshu
ZHENG Meizhu
MA Sugang
YU Zhiyong
Abstract：Objective To investigate the correlation between p53 and EGFR overexpression in distinct mo-lecular subtypes of invasive breast cancer. Methods The clinicopathology data of 264 operable breast cancer patients from January 2012 to August 2013 were retrospectively analyzed, and the correlation of p53 and epider-mal growth factor receptor ( EGFR) expression in distinct molecular subtypes was investigated. Results No sta-tistically significant differences were found among distinct molecular subtypes regarding age at diagnosis and age at menarche by using chi-square test(all P>0. 05). Statistically significant differences were found among dis-tinct molecular subtypes regarding menopause status, tumor size, lymph node status, pathological stage , Cytok-eratin 5/6 (CK5/6), p53 and EGFR (all P<0. 05). There were more patients with T1 stage in Luminal sub-type than that of in non-luminal subtype (P<0. 05). p53 expression had a positive correlation with EGFR ex-pression in invasive breast cancer (r=0. 226,P<0. 05). There was a significant positive correction between p53 and EGFR in triple-negative breast cancer (TNBC) by stratification analysis (r=0. 319,P<0. 05), not in other subtypes(all P>0. 05). Conclusions There was a positive correlation between p53 and EGFR in TNBC. P53 and EGFR in TNBC may help us to comprehensively recognize the molecular biological characteristics of TNBC,and may offer us a new idea to TNBC treatment.
Keywords：breast cancermolecular subtypeimmunohistochemistryp53EGFR
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 78-82 )