Relationship between monocyte chemoattactant protein-1 gene polymorphism and susceptibility of esoph-ageal cancer
CUI Bin
BU Chunying
FU Ping
Abstract：Objective To investigate the association between monocyte chemoattactant protein-1 gene poly-morphism and the susceptibility of ESCC in Han nationality.Methods Polymerase chain reaction (PCR)and DNA direct sequencing were used to detect the MCP-1-2518 gene polymorphism in 202 patients suffering from ESCC,265 healthy patients were chosen as control group.Results The overall genotype and allele distribution of MCP-1-2518 gene polymorphism in the ESCC patients were not significantly different from those in the healthy control group,(P >0.05).There was evidence of stratified analysis based on the smoking case showed that the smokers with AA genotype significantly increased the risk to develop ESCC (sex and age adjusted OR =3.064, 95%CI =1.397 ~6.718)compared with MCP-1-2518 GG genotype.However,MCP-1-2518 allele was no sig-nificantly different from both the non-smoking ESCC group and healthy group,(P >0.05 ).Conclusions MCP-1-2518 gene polymorphism is not independently associated with the susceptibility of ESCC.MCP-1-2518 AA allele may increase the susceptibility of ESCC among smokers in Jinan area.
Keywords：monocyte chemoattactant protein-1esophageal cancersusceptibilitygene polymor-phism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 382-384 )