Preoperative short-course radiotherapy versus preoperative chemo-radiotherapy for stage Ⅱ or Ⅲ rectal cancer:a Meta-analysis
LIU Juying
CHEN Zhenzhang
LIU Yatian
CHEN Wei
WANG Feijiang
HE Xia
Abstract：Objective To compare the therapeutic effect and toxic reaction between preoperative short-course radiotherapy(SCRT)and preoperative chemo-radiotherapy(CRT)for stage Ⅱ or Ⅲ rectal cancer.Meth-ods Original articles were searched in the Pubmed,EMbase,Cochrane Library,China Journal Full-text Data-base,Wanfang Database and Chinese sci-tech periodical full-text database.Randomized controlled trials compa-ring preoperative short-course radiotherapy and preoperative chemo-radiotherapy for stage Ⅱ or Ⅲ rectal cancer in accordance with the inclusion and exclusion criteria were included.Data extracted from these trials were ana-lyzed by the software named as RevMan 5.3.Results A total of 2 randomized controlled trials were included. The results of Meta-analysis showed that the SCRT group is less than CRT group in T downstage rate(RR =0.64,95%CI:0.53 ~0.77,P <0.05),and pathological complete response rate(RR =0.06,95%CI:0.02 ~0.19,P <0.05).There was no significant difference in the rate of sphincter preservation,local recurrence rate, overall survival rate and severe late toxicity rate between the two groups.Conclusions As compared with pre-operative SCRT,CRT can improve the T downstage rate and complete pathologic response rate for stage Ⅱ or Ⅲrectal cancer.
Keywords：rectal cancerpreoperative short-course radiotherapypreoperative chemo-radiotherapyMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 367-371 )