Expression of Her3 in colon cancer and its relationship of proliferation and apoptosis of colon cancer cells
GAO Jun
LV Long
CHEN Gong
Abstract：Objective To investigate the expression of Her3 in colon cancer and study the effect and mech-anism of Her3 in colon cancer cell lines. Methods The expression of Her3 in human colon cancer was deter-mined by both real-time PCR and IHC. The possible mechanism was further analyzed by siRNA knock-down as-say in vitro. Results It had werified that expression of Her3 in human colon cancer tissues compared with ad-jacent normal tissues grew sighificantly. Study revealed that knockdown of expression of Her3 led to impaired proliferation and increased apoptosis in human colon cancer cell lines,meanwhile reduced activation of both AKT and MAPK signaling were detected. Conclusions Her3 is excessive expressed in human colon cancer and related to proliferation and survival of colon cancer cell lines in vitro,which is partially due to activation of AKT signaling.
Keywords：Her3colon cancerproliferationapoptosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 298-302 )