Cardio-protective effect of dexrazoxane injection for patients under theprubicin chemotherapy treatment
FENG Lingfei
HE Zeng
Abstract：Objective To explore the cardio-protective effect of dexrazoxane injection for breast cancer pa-tients under theprubicin chemotherapy treatment. Methods 80 cases of breast cancer patients under theprubi-cin chemotherapy were randomly divided into two groups,40 cases in each group. Patients in the observation group were given TAC (taxotere+theprubicin+ cyclophosphamide)and dexrazoxane injection,the allocation ratio of dexrazoxane injection was 10 times of theprubicin,and patients in the control group were given TAC and placebos. Electro-cardiogram,left ventricular ejection fraction (LVEF)and adverse reactions at different treat-ment stages in the two groups were analyzed and compared accordingly. Results There were abnormal differ-ences of electro-cardiogram in 2 groups and LVEF changes were statistically significant (P<0. 05). During the start of treatment and one year follow-up period after treatment,the LVEF of observation group had no significant difference(P>0. 05),the gastrointestinal reactions,occurrences of alopecia in the observation group at treatment phase were less than those in control group (P <0. 05). Conclusion Dexrazoxane injection can improve cardi-ac resistance effect of breast cancer patients who were under theprubicin-containing chemotherapy and reduce their adverse reaction.
Keywords：dexrazoxanebreast cancertheprubicincardiac toxicity
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 292-293,302 )