Screening and optimization of tumor markers and determination of cutoff value in ovarian cancer pa-tients
ZHOU Guangzheng
Abstract：Objective The aim of this work is to screen suitable tumor markers (TMs)and to determine their cutoff values in patients with ovarian cancer. Methods Serum samples of 179 women,including 77 ovari-an cancer(group A),62 ovarian benign cysts(group B),and 40 healthy controls(group C),were tested for CA153,CA724,CA125 and Human Epididymis Protein 4(HE4)using fully automated instruments (Roche Elecsys cobas E). Risk of Ovarian Malignancy Algorithm(ROMA)values were calculated according to refer-ences. Differences of tumor marker concentration among three groups were evaluated by SPSS software. Using Receiver Operating Characteristics (ROC)curve,the cutoff values of tumor markers were determined. Results Significant differences of TMs between group A and group B,also group A and group C,were observed(P<0. 05). ROMA was the best diagnostic item with a good sensitivity(0. 94)and specificity(1. 00),and the other recommended diagnostic items for ovarian cancer were HE4(0. 89 for sensitivity and 0. 97 for specificity)and CA125(0. 83 and 0. 91,respectively). According to area under the curve(AUC),the diagnostic ability of TMs for ovarian cancer was,successively,ROMA,HE4,CA125,CA153,CA724. Conclusions This study show that CA125,HE4 and ROMA should be recommended to diagnosis ovarian cancer,and the preliminary cutoff values for CA125,HE4 and ROMA are 90. 96 U/ml,81. 38 pmol/l and 37. 22 %,respectively.
Keywords：tumor markerHE4CA125ROMAROC
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 288-291 )