Clinical analysis and safety evaluation of preoperative concurrent chemo-radiotherapy for patients with locally advanced cervical cancer
SHAO Jia
HE Aiqin
CHEN Zengyan
Abstract：Objective To evaluate the efficacy and safety of preoperative concurrent chemo-radiotherapy in patients with locally advanced cervical cancer. Methods 70 patients with stageⅠb2 andⅡa2 cervical cancer were treated by PVB,TP or TC chemotherapy program and brachytherapy before radical hysterectomy from Jan. 2007 to Dec. 2010. The changes of local cervical tumor and the toxicity of concurrent chemo-radiotherapy in pa-tients were observed and its efficacy and safety were analyzed accordingly. Results The complete remission and partial remission were 14 cases and 45 cases in 70 patients;total effective rate was 84. 3%. Three-year lo-cal recurrence rate was 31. 3%,three-year distant metastasis rate was 25. 4% and three-year overall survival rate was 79. 1%. The incidence of adverse reaction,bone marrow suppression was 30. 0%(21/70),peripher-al neurotoxicity was 10. 0%(7/70),gastrointestinal reaction was 80. 0%(56/70),muscle and joint pain, 12. 9%(9/70),hair loss was 87. 1%(61/70). The mean operative blood loss was 410 ml,mean operation time was 160 minutes. There were 2 cases of postoperative urinary fistula,12 cases of postoperative urinary re-tention and 1 case of pelvic lymphocyte infection,all patients were cured after symptomatic treatment. Conclu-sions Preoperative concurrent chemo-radiotherapy for locally advanced cervical cancer patients can achieve i-deal treatment results:toxicity can be tolerated and does not affect subsequent treatment,postoperative compli-cations are minor. Preoperative concurrent chemo-radiotherapy has good prospects for clinical application.
Keywords：cervical cancerlocally advancedconcurrent chemo-radiotherapybrachytherapyefficacy evaluation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 282-284,287 )