The expression of nicotinamide phosphoribosyl transferase in breast cancer and its clinical significance
BI Tieqiang
ZHOU Jun
LIANG Wenxue
LIU Yi
LI Shuqin
GAO Xitao
SHEN Jun
WANG Peishun
Abstract：Objective To study the expression of nicotinamide phosphoribosyl transferase( Nampt)in breast cancer and investigate their correlations to clinicopathological features and prognostic significance. Meth-ods The proteins of Nampt in 83 breast cancer specimens and corresponding normal breast tissue specimens were detected by immunohistochemistry. Nampt expression was correlated with clinico-pathological variables u-sing the Chi-square test. The prognostic value of visfatin for overall survival was evaluated by Kaplan-Meier esti-mates. Results Nampt in breast cancer was significantly higher than that in normal breast tissue;the expres-sion of Nampt was correlated to tumor size,lymph node metastasis,clinical TNM stage,estrogen receptor(ER) negativity,and progesterone receptor(PR)negativity. High Nampt expression was associated with poor disease-free survival and overall survival. Conclusions The expression of Nampt is positively correlated with more ma-lignant cancer behavior as well as poor patient survival in breast cancer.
Keywords：breast cancernicotinamide phosphoribosyl transferaseimmunohistochemistryprog-nosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 218-221 )