Clinical significance of miR-17 in expression in colorectal cancer
GUI Liang
WANG Taihong
ZHANG Hongwei
LU Yousheng
Abstract：Objective To investigate the expression of miR-17 in colorectal cancer(CRC)and its relation-ship with clinicopathological features. Methods Quantitative real-time PCR was applied to examine the expres-sion of miR-17 in 50 primary CRC specimens which were diagnosed and operated in our hospital between 2012. 01 and 2013. 06,in comparison with the corresponding normal mucosa specimens. The relationship between the expression of miRNAs and clinicopathological features was analyzed. Results The expression of miR-17 in CRC was down-regulated by compared to normal mucosa(P ﹤ 0. 05). Furthermore,the expression of miR-17 was related to TNM stage and local invasion(P ﹤ 0. 05). Conclusions The down-expression of miR-17 may play an important role in the progression of CRC.
Keywords：colorectal cancerreal-time PCRmiR-17
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 215-217 )