Research progress in the autoinflammatory disease osteolytic osteomyelitis and membrane-regulating protein PSTPIP2
HUO Qingran
DONG Ge
CAI Zhigang
Abstract：Innate immunity,as the first line of defense for the body against the invasion of pathogens,plays a significant role in maintaining the homeostasis of the immune system,and in recognizing and eliminating the invading pathogens.However,under aseptic conditions,the abnormal activation of innate immunity may induce autoinflammatory diseases.Chronic recurrent multifocal osteomyelitis(CRMO),as a typical representative of autoinflammatory diseases,still has many fundamental theoretical and clinical management problems that need to be urgently solved in clinical diagnosis and treatment.The Pstpip2-/-mouse model is widely used in the research fields of autoinflammatory diseases and CRMO,which facilitates the understanding of the regulatory mechanisms of CRMO at the molecular and cellular levels.This paper summarizes the clinical manifestations and classifications of general autoinflammatory diseases,with a focus on discussing the role of membrane-regulating protein proline-serine-threonine-phosphatase-interacting protein 2(PSTPIP2)in the Pstpip2-/-mouse model of CRMO,aiming to provide a reference for analyzing the pathogenesis of osteolytic osteomyelitis and formulating therapeutic strategies.
Keywords：Innate immunityAutoinflammatory diseasesOsteolytic osteomyelitisMembrane-regulating protein proline-serine-threonine-phosphatase-interacting protein 2(PSTPIP2)
Publication Date：2026-02-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：6( 166-171 )