The delayed complete virological response to nucleos(t)ide analogue therapy in chronic HBV-infected patients with immune tolerance state
GAO Lin
FENG Yinong
JIANG Qianqian
DING Yang
ZHENG Sujun
WANG Lei
WU Xiaoping
LU Fengmin
Abstract：Expanding antiviral treatment for chronic hepatitis B(CHB)is gradually becoming a consensus.In the future,more patients with the immune tolerance state of high baseline hepatitis B virus(HBV)deoxyribonucleic acid(DNA)levels will be included in antiviral treatment.Because these patients lack the host immune-mediated covalently closed circular DNA(cccDNA)clearance effect,it is expected that they will often need a longer time to achieve complete control of viral DNA replication when receiving antiviral treatment with nucleos(t)ide analogues(NAs),which is complete response postpone(CRP).Therefore,it is not appropriate to simply classify the delayed complete virological response to NAs as low-level viremia(LLV)with poor response to antiviral therapy,in order to avoid treatment hesitancy or adjust the clinical treatment regimes too early.
Keywords：Hepatitis B virus(HBV)Immune toleranceVirological response
Publication Date：2026-02-28
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：6( 117-122 )