Study on the association of serum D-dimer,BAFF and E2 levels with outcomes of frozen-thawed embryo transfer in patients with endometriosis complicated with infertility
FENG Chengwen
FAN Yanling
LIU Baolian
Abstract：Objective To investigate the association of serum D-dimer(D-D),B cell activating factor(BAFF)and estradiol(E2)levels with outcomes of frozen-thawed embryo transfer(FET)in patients with endometriosis(EMs)complicated with infertility.Methods A total of 116 patients with EMs complicated with infertility who were admitted to Department of Reproductive Genetics,Tangshan Maternal and Children Health Hospital from August 2022 to August 2024 were recruited.The patients were divided into pregnancy group(n=64)and non-pregnancy group(n=52)according to their FET outcomes.The general data and the levels of serum D-D,BAFF and E2 on the first day before performing FET were compared between the two groups.Multivariate logistic regression was used to analyze the factors influencing the FET outcomes of the patients with EMs complicated with infertility.The efficacy of serum D-D,BAFF and E2 levels in predicting failure to conceive in the patients with EMs complicated with infertility after receiving FET was analyzed by using receiver operating characteristic(ROC)curve.Results The levels of serum D-D,BAFF and E2 in the non-pregnancy group were significantly higher than those in the pregnancy group(P＜0.05).The results of multivariate logistic regression analysis showed that higher levels of serum D-D[OR(95%CI)=1.346(1.056-1.716)],BAFF[OR(95%CI)=1.439(1.027-2.016)]and E2[OR(95%CI)=1.652(1.121-2.435)]were independent risk factors for failure to conceive in the patients with EMs complicated with infertility after receiving FET(P＜0.05).The results of ROC curve analysis showed that the levels of serum D-D,BAFF and E2 could effectively predict failure to conceive in the patients with EMs complicated with infertility after receiving FET(P＜0.05),and the predictive efficacy of the combination of the three indicators was significantly better than that of a single indicator(Zcombination of the three indicators-D-D=2.875,P=0.004;Zcombination of the three indicators-BAFF=3.205,P=0.001;Zcombination of the three indicators-E2=3.791,P＜0.001).Conclusion The elevated levels of serum D-D,BAFF and E2 are risk factors for FET failure in the patients with EMs complicated with infertility.The combined detection of the three indicators is helpful for the early identification of high-risk patients and active intervention,thereby improving the success rate of FET.
Keywords：Endometriosis(EMs)Frozen-thawed embryo transfer(FET)InfertilityD-dimer(D-D)B cell activating factor(BAFF)Estradiol(E2)
Publication Date：2026-01-30
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 47-51 )