Levels and clinical significance of D-D,25(OH)D,LMR and IL-6 in patients with sepsis
YANG Wei
LIU Shuangqing
ZHANG Ling
FANG Weihua
YU Shengyang
XIE Tao
HUANG Qiuli
LIU Xiaoyi
Abstract：Objective To analyze the levels and clinical significance of D-dimer(D-D),25-hydroxyvitamin D[25(OH)D],lymphocyte-to-monocyte ratio(LMR)and interleukin-6(IL-6)in patients with sepsis.Methods Fifty-five patients with sepsis who were admitted to the 73th Group Military Hospital of People's Liberation Army from June 2022 to June 2024 were selected as observation group.Other 50 healthy individuals who underwent physical examination during the same period were selected as control group.The levels of plasma D-D,serum 25(OH)D and serum IL-6 were detected for the patients at admission or for the control group during physical examination and LMR was calculated.According to the survival status of the patients within 3 months after admission,they were divided into death group(15 patients)and survival group(40 patients).Multivariate logistic regression was used to analyze the factors influencing the occurrence of death in the sepsis patients.The efficacy of D-D,25(OH)D,LMR and IL-6 for predicting mortality in the sepsis patients was analyzed by using receiver operating characteristic(ROC)curve.Results The D-D and IL-6 levels in the observation group were higher than those in the control group,while the 25(OH)D level and LMR in the observation group were lower than those in the control group,with statistically significant differences between the two groups(P＜0.05).The Sequential Organ Failure Assessment(SOFA)scores,D-D level and IL-6 level in the death group were higher than those in the survival group,while the 25(OH)D level and LMR in the death group were lower than those in the survival group,with statistically significant differences between the two groups(P＜0.05).Higher SOFA scores,D-D level and IL-6 level were risk factors for death in the sepsis patients,while higher 25(OH)D level and LMR were protective factors for survival in the sepsis patients(P＜0.05).The efficacy of the combined detection of D-D,25(OH)D,LMR and IL-6 for predicting mortality in the sepsis patients[AUC(95%CI)=0.834(0.759-0.909)]was superior to that of the detection of a single indicator(P＜0.05),and the sensitivity and specificity were93.33%and87.50%,respectively.Conclusion The levels of plasma D-D and serum IL-6 in sepsis patients increase,while the levels of serum 25(OH)D and LMR in them decrease.The combined detection of these four indicators can effectively predict the prognosis of the sepsis patients.
Keywords：SepsisD-dimer(D-D)25-Hydroxyvitamin D[25(OH)D]Immune cellsInterleukin-6(IL-6)
Publication Date：2026-01-30
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：6( 41-46 )